About KALPAS
Our study utilizes a 3-arm placebo-controlled RCT to study the effectiveness of ketamine in reducing chronic post-mastectomy pain. Participants randomized to the first arm will receive a 0.35mg/kg dose after induction, followed by a 0.25mg/kg/hr infusion during surgery (up to a maximum of 6 hours) and continued for 2hours postoperatively. Participants in the second arm will receive a single dose of 0.6mg/kg of ketamine in the post-anesthesia care unit, and the final group will serve as the control group and receive saline (no ketamine).
Study Team
Jing Wang, MD, PhD
Study PI
NYU Grossman School of Medicine
Lisa Doan, MD
Study PI
NYU Grossman School of Medicine
Uchenna O. Umeh, MD
PPAM Study PI
Hospital for Special Surgery/Weill Cornell Medicine
Randy Cuevas, MPA
Project Manager
NYU Grossman School of Medicine
Deborah Axelrod, MD
Co-Investigator
NYU Grossman School of Medicine
Michele Curatolo, MD, PhD
Co-Investigator
University of Washington
Robert Edwards, PhD
Co-Investigator
Brigham and Women's Hospital
Study Site Locations
- Brigham and Women’s Hospital – Harvard University
- Magee Women's Hospital – University of Pittsburgh Medical Center
- Mayo Clinic – Rochester, Minnesota
- Memorial Sloan Kettering Cancer Center
- Montefiore Medical Center – Albert Einstein College of Medicine
- NY Presbyterian Columbia University Irving Medical Center
- NYU Langone Hospital – Kimmel
- NYU Langone Hospital – Tisch
- Rush University Medical Center
- University of Alabama at Birmingham
- University of Arkansas Medical Center
- University of Cincinnati
- University of Texas – MD Anderson Cancer Center
- University of Texas – Southwestern Medical Center
- University of Washington Medical Center
- Washington University St. Louis Medical Center